SHaReResearchat a Glance

Summaries of research studies were made possible by analyzing the data in the SHaRe Registry.       SHaRe Research Library.

Genotype and Lifetime Burden of Disease in Hypertrophic Cardiomyopathy: Insights from the Sarcomeric Human Cardiomyopathy Registry (SHaRe)

A better understanding of the factors that contribute to heterogeneous outcomes and lifetime disease burden in hypertrophic cardiomyopathy (HCM) is critically needed to improve patient management and outcomes. The Sarcomeric Human Cardiomyopathy Registry (SHaRe) was established to provide the scale of data required to address these issues, aggregating longitudinal datasets curated by eight international HCM specialty centers.

Care in Specialized Centers and Data Sharing Increase Agreement in Hypertrophic Cardiomyopathy Genetic Test Interpretation

Genetic testing for cardiovascular diseases like Hypertrophic Cardiomyopathy (HCM) has become common practice. However, genetic testing can only help patients and families with HCM if genetic test results interpreted accurately. Sometimes genetic test results can be challenging to interpret and experts disagree on the interpretation. This study looked at how different HCM experts interpret genetic tests.

Mulitdimensional structure-function relationships in human B-cardiac myosin from population-scale genetic variations.

In this study researchers looked at whether the genetic changes in the heart myosin that cause HCM tend to occur more often in certain areas of the molecule. In addition, the researchers looked at how different genetic changes contribute to differences in disease onset and disease outcomes of patients with Hypertrophic Cardiomyopathy.


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